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All Journal Majalah Kedokteran Sriwijaya Sriwijaya Journal of Ophthalmology Ophthalmologica Indonesiana
Devi Azri Wahyuni
Department Of Ophthalmology, Faculty Of Medicine, Universitas Sriwijaya Mohammad Hoesin Hospital, Palembang, South Sumatera
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Physics Public Health

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Journal : Sriwijaya Journal of Ophthalmology

 1 
Comparison of Copper Level and Color Vision in Pulmonary Tuberculosis Patients Before and After Ethambutol Treatment in Category I and II Febria Restissa; Ahmad Rasyid; Devi Azri Wahyuni
Sriwijaya Journal of Ophthalmology Vol. 3 No. 1 (2020): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.702 KB) | DOI: 10.37275/sjo.v3i1.39

Abstract

Introduction: to determine the correlation between duration of ethambutol and copper levels in serum with color vision disorder examined with Farnsworth Munsell 100 Hue (FM100) in patients with tuberculosis. Methods: This study was an explorative observation of 20 samples during November 2017 - January 2018 period. Comparative analysis using independent t-test, paired t-test, Wilcoxon test and Mann-Whitney test, while correlation analysis using Spearman's test and Pearson's test. Results: There was a significant difference of FM100 value before and after in category I (p=0.000) with increase of total error value 11.80+5.31 or category II (p=0.000) with increase of total error value 15.00+7.41. There was significant difference of Cu2+ level before and after in category I (p=0.005) with decrease of Cu2+ level 15.57+5.04 mg/dL or category II (p=0.005) with decrease of Cu2+ level 31.66+7.35 mg/dL. There was significant correlation between color vision and duration of ethambutol (p=0.000), but there was no significant correlation of Cu2+ with color vision (p>0.05). Conclusion: The duration of Ethambutol was related to changes in color vision examined with FM100.
Factors Affecting Generalization of Ocular Myasthenia Gravis in Palembang Zahratul Riadho Farid; Devi Azri Wahyuni
Sriwijaya Journal of Ophthalmology Vol. 3 No. 2 (2020): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v3i2.55

Abstract

Introduction: Ocular myasthenia gravis (OMG) is an autoimmune disease which is characterized by weakness of extraocular muscles, levator palpebrae and orbicularis oculi, resulting in ptosis and binocular diplopia. Nearly all patients present with eyelid and extra ocular muscles involvement. Approximately 30% to 80% of patients with OMG experience a conversion to generalized myasthenia gravis (GMG) within 2 years. There are not only have ptosis and diplopia but also limb weakness,bulbar symptoms, or even respiratory failure. Objective: To observe the clinical features of OMG to GMG and risk factors and median time to conversion of OMG to GMG of myasthenia gravis patients in Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study is a cohort retrospective study and the data were collected from the medical records of 91 patients who were registered as myasthenia gravis patients during September 2018 to March 2020. Sosiodemographic and clinical characteristics, including onset of OMG to GMG, history of smoking, presence of thymic abnormalities, and medications received were reviewed retrospectively. Results: A total of 91 OMG patients were observed in this study with 32 (35,2%) patients converted from ocular myastenia gravis to general myastenia gravis. Median conversion time to GMG was 34 months. Risk factor for convertion cases of OMG to MGG was receiving immunosupressive agents (Risk: 14.7, 95% CI 4.83, 44.7), thymus hyperplasia (Risk: 3.36, CI 95% 0.33, 33.6), Female (Risk: 2.41, 95% CI 0.94, 6.17), Smoking (Risk: 1.56, 95% CI 0.31, 7.81). Conclusion: Ptosis was the definitive sign for OMG in this study, with all patients had ptosis, thus it needs the colaboration from neuroophthalmologist and neurologist to diagnose and manage this case. Most of converted case was female and those who receive an immunosupressive agent therapy.
Co-Authors Agus Nugroho Ahmad Rasyid Ahmad Rasyid Erial Bahar Febria Restissa Febria Restissa Frida Lestari Mgs Irsan Saleh Mira Retna Tetiana Nafila Mahida Sukmono Nyayu Fauziah Zen Yuventius Odie Devanand Zahratul Riadho Farid